Propanol

CAS

Purity

CHARACTER

propanol, chemical name 1-propanol, is a colorless and transparent liquid with similar alcohol odor, chemical formula C3H8O, molecular weight 60.10. It has good solubility and volatility, and can be miscible with water, ethanol and other solvents. It is an important raw material in the fields of chemical industry, medicine, paint, printing ink and cosmetics. N-propanol is used in the pharmaceutical industry to produce drugs, such as analgesics and antibacterial agents; in the chemical industry, it is an important component in the production of plasticizers, resins and coatings; at the same time, n-propanol is also used in the production of fragrances, surfactants and products such as dyes. Its wide range of applications and excellent chemical properties make n-propanol one of the most popular raw materials in industrial production.

APPLICATIONS

(1) n-Propanol has important applications in the field of organic synthesis. It can be used as a raw material to generate pharmaceutical intermediates and pesticide intermediates, so it is widely used in the production of pharmaceuticals and pesticides.

(2) n-propanol is used as a solvent because of its excellent solubility, and can be used in nitro spray paint, cosmetics, dental detergents, inks, plastics and other industries. It can also be used as a solvent directly or after synthesis of n-propyl acetate for coating solvents, printing inks and other fields.

(3) n-propanol can be used in the production of feed additives, synthetic spices, etc. It is an important raw material in many fields such as food additives, detergents, preservatives and brake oils.

(4) n-propanol can be used as a mixed fuel with alkanes and alkenes to increase the temperature during combustion and improve energy efficiency.

(5) n-propanol can replace the lower boiling point of ethanol, used as a solvent for some synthetic resins and ethyl cellulose, polyvinyl butyral, vegetable oils, natural rubber and resins.

(6) Derivatives of n-propanol, such as n-propylamine, also have many applications in pharmaceutical and pesticide production, and can be used to produce a variety of pesticide products.

(7) n-Propanol can also be used as a chromatography reagent and chromatography reagent, which plays an important role in the field of chemical analysis.

(8) In addition, n-propanol is also used in the electrolyte of new energy vehicles to support the development of new energy vehicles.

INDICATORS

ABILITIES

1. Packing: barreled, scattered water
2. Logistics: car transportation, shipping
3. Payment request: EXW/FOB/FCA/CFR only accepted

HONORARY

Chinese name	Propanol
English Name	1-Propanol
Alias	Propanol n-Propanol Natural Propanol 1-Propanol Natural n-Propanol 1-Propanol, Propanol n-Propanol Standard Solution 1-Propanol, SPECTROPHOTOMETRIC GRADE
English alias	n-C3H7OH Propanol 1-Propanol n-Propanol Propan-1-ol Propyl Alcohol femanumber2928 ethyl carbinol alcoolpropilico n-propyl alcohol n-ppropylalcohol alcoolpropylique Natural Propyl Alcohol alcoolpropylique(french) epapesticidechemicalcode047502
CAS	71-23-8
EINECS	200-746-9
Chemical formula	C3H8O
molecular weight	60.1
InChI	InChI=1/C3H8O/c1-2-3-4/h4H,2-3H2,1H3
Density	0.804 g/mL at 25 °C(lit.)
Melting Point	-127°C(lit.)
Boiling Point	97°C(lit.)
Flash Point	59 °F
water soluble	soluble
Vapor pressure	10mm Hg ( 147 °C)
steam density	2.1 (vs air)
JECFA Number	82
Solubility	H2O: Pass the test
refractive index	n20/D 1.384(lit.)
acidity coefficient	>14 (Schwarzenbach et al., 1993)
PH value	7 (200g/l, H2O, 20℃)
Storage conditions	Store at +5°C to +30°C.
Stability	Stable. Contact with air may form peroxides. Incompatible with alkali metals, alkaline earth metals, aluminum, oxidants, nitro compounds. Highly flammable. Explosive vapor/air mixture.
Appearance	Solid
Color	<10(APHA)
Smell	Resembles that of ethyl alcohol.
Maximum wavelength (λmax)	['λ: 220 nm Amax: ≤0.40', , 'λ: 240 nm Amax: ≤0.071', , 'λ: 275 nm Amax: ≤0.0044']
Merck	14,7842
BRN	1098242
Explosion limit value	2.1-19.2%(V)
Exposure Limits	TLV-TWA (200 ppm); (500 mg/m3); STEL250 ppm (625 mg/m3); IDLH 4000 ppm.
physicochemical properties	Colorless transparent liquid, similar to the smell of ethanol.
Dangerous Goods Signs	F-INFLAMMABLE Xi-Irritant
Risk Terms	R11-Highly flammable. R41-Serious injury to eyes. R67-Vapor may cause drowsiness and dizziness.
Safety terminology	S7-Keep container sealed. S16-Keep away from sources of ignition. S24-Avoid skin contact. S26-After contact with eyes, rinse immediately with plenty of water and seek medical advice. S39-Wear goggles or mask.
Dangerous Goods Transport No.	UN 1274 3/PG 2
WGK Germany	1
RTECS	UH8225000
FLUKA BRAND F CODES	10-23
TSCA	Yes
Customs Number	29051200
Hazard Class	3
Packing Group	II
Upstream raw materials	Propionaldehyde
Downstream Products	propyl p-hydroxybenzoate erythromycin

n-Propanol- Properties

Colorless clear liquid with ethanol-like odor. Combustible. Melting point -127 ℃; Boiling point 97.2 ℃; Can be miscible with water, alcohol, ether, hydrocarbon and other solvents. The chemical properties of n-propanol are similar to other low molecular weight primary aliphatic alcohols. It is miscible with water, ethanol and ether. Its vapor and air form an explosive mixture, which can cause combustion and explosion when exposed to open flame and high heat. Can react strongly with oxidants.

n-Propanol- preparation method

Propionaldehyde is synthesized from ethylene by carbonylation, and then n-propanol is obtained by hydrogenation. Alternatively, n-propanol is directly generated from ethylene and water using a metal carbonyl compound as a catalyst. It can also be prepared by liquid phase oxidation using propane or butane as raw material.

n-Propanol- Uses

Generally used as a solvent. Can be used for coating solvents, printing inks, cosmetics, etc., used in the production of pharmaceuticals, pesticides intermediates n-propylamine, used in the production of feed additives, synthetic spices, etc. Propanol in the pharmaceutical industry, food additives, plasticizers, spices and many other aspects are widely used.

n-Propanol- Safety

Rat oral LDso:1870 mg/kg. Headache, drowsiness and eye, nose and throat irritation may occur when exposed to high concentrations of steam. The staff shall be well protected and the working environment shall be well ventilated. Store in a cool, ventilated warehouse. Should be stored separately from the oxidizer. Keep away from fire and heat source. Prevent direct sunlight. Keep container sealed.

n-Propanol- Introduction

Propanol, also known as isopropanol, is an organic solvent. The following is a description of the properties, uses, methods and safety information of propanol:

properties:
-propanol is a colorless liquid with a unique smell of alcohols.
-It can dissolve water, ethers, ketones and many organic substances.

uses:
-propanol is widely used as a solvent in industry for the manufacture of paints, coatings, cleaning agents, dyes and pigments.

preparation method:
-propanol can be prepared by hydrogenation of methane hydrate.
-Another commonly used method of preparation is by direct hydrogenation of propylene and water.

safety information:
-propanol is flammable and should be kept away from open flames and high temperatures.
-Wear appropriate protective equipment such as gloves, goggles and protective clothing when handling propanol.

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Chemical Safety Data Sheet MSDS / SDS

1-Propanol

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: 1-Propanol
CBnumber: CB9854149
CAS: 71-23-8
EINECS Number: 200-746-9
Synonyms: 1-propanol,propanol

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P405 Store locked up.

P403+P235 Store in a well-ventilated place. Keep cool.

P370+P378 In case of fire: Use … for extinction.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Hazard statements

H336 May cause drowsiness or dizziness

H318 Causes serious eye damage

H225 Highly Flammable liquid and vapour

SECTION 3: Composition/information on ingredients

Substance

Product name: 1-Propanol
Synonyms: 1-propanol,propanol
CAS: 71-23-8
EC number: 200-746-9
MF: C3H8O
MW: 60.1

SECTION 4: First aid measures

Description of first aid measures

General advice

Show this material safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air. Call in physician.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.

In case of eye contact

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.

If swallowed

After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Carbon dioxide (CO2) Foam Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Combustible.

Pay attention to flashback.

Vapors are heavier than air and may spread along floors.

Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures.

Advice for firefighters

In the event of fire, wear self-contained breathing apparatus.

Further information

Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.

Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.

Environmental precautions

Do not let product enter drains. Risk of explosion.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb? ). Dispose of properly. Clean up affected area.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Avoid generation of vapours/aerosols.

Advice on protection against fire and explosion

Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.

Hygiene measures

Change contaminated clothing. Wash hands after working with substance. For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and

sources of ignition.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Full contact

Material: Nitrile rubber

Minimum layer thickness: 0,4 mm Break through time: 480 min

Material tested:Camatril? (KCL 730 / Aldrich Z677442, Size M)

Splash contact Material: Chloroprene

Minimum layer thickness: 0,65 mm Break through time: 120 min Material tested:KCL 720 Camapren?

Body Protection

Flame retardant antistatic protective clothing.

Respiratory protection

Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

Control of environmental exposure

Do not let product enter drains. Risk of explosion.

Exposure limits

TLV-TWA (200 ppm); (500 mg/m³); STEL 250 ppm (625 mg/m³); IDLH 4000 ppm.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearancecolorless clear, liquid
Odouralcohol-like
Odour Threshold2,6 ppm
pH8,5 at 200 g/l at 20 °C
Melting point/freezing pointMelting point/range: -127 °C - lit.
Initial boiling point and boiling range97 °C - lit.
Flash point22 °C - closed cup
Evaporation rate1
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limitsUpper explosion limit: 13,7 %(V) Lower explosion limit: 2,1 %(V)
Vapour pressure19,3 hPa at 20 °C
Vapour density2,07 - (Air = 1.0)
Relative density0,804 g/cm3 at 25 °C - lit. No data available
Water solubilityat 20 °C completely miscible
Partition coefficient: n-octanol/waterlog Pow: 0,2 at 25 °C - Bioaccumulation is not expected.
Autoignition temperature400 °C at 1.013,25 hPa - DIN 51794
Decomposition temperatureNo data available
ViscosityViscosity, kinematic: No data available Viscosity, dynamic: 2,21 mPa.s at 20 °C
Explosive propertiesNo data available
Oxidizing propertiesNo data available
Henry's Law Constant6.75 (static headspace-GC, Merk and Riederer, 1997)
λmaxλ: 220 nm Amax: ≤0.40
λ: 240 nm Amax: ≤0.071
λ: 275 nm Amax: ≤0.0044

Other safety information

Surface tension 23,45 mN/m at 20 °C

Relative vapor density

2,07 - (Air = 1.0)

SECTION 10: Stability and reactivity

Reactivity

Vapors may form explosive mixture with air.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

Exothermic reaction with:

Alkaline earth metals alcoholates

Alkali metals Release of:

Hydrogen

Violent reactions possible with:

Strong oxidizing agents

Conditions to avoid

Warming.

Incompatible materials

rubber, various plastics

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

Oral
Symptoms: Risk of aspiration upon vomiting., Aspiration may cause pulmonary edema and pneumonitis.
LC50 Inhalation - Rat - male and female - 4 h - > 33,8 mg/l (OECD Test Guideline 403)
Symptoms: Possible damages:, mucosal irritations LD50 Dermal - Rabbit - male - 4.032 mg/kg (OECD Test Guideline 402)

Skin corrosion/irritation

Skin - Rabbit
Result: No skin irritation (OECD Test Guideline 404)

Serious eye damage/eye irritation

Eyes - Rabbit
Result: Causes serious eye damage. (OECD Test Guideline 405)

Respiratory or skin sensitization

Remarks: (ECHA) Patch test: - Human
Result: negative Remarks: (IUCLID)

Germ cell mutagenicity

Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471
Result: negative
Test Type: In vitro mammalian cell gene mutation test Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 476
Result: negative
Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 473
Result: negative

Carcinogenicity

No data available

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

May cause drowsiness or dizziness. - Central nervous system

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

Toxicity

LD50 orally in rats: 1.87 g/kg (Smyth)

SECTION 12: Ecological information

Toxicity

Toxicity to fish

flow-through test LC50 - Pimephales promelas (fathead minnow) -

4.555 mg/l - 96 h

(OECD Test Guideline 203)

Toxicity to daphnia and other aquatic invertebrates

static test EC50 - Daphnia magna (Water flea) - 3.644 mg/l - 48 h (DIN 38412)

Toxicity to algae

static test ErC50 - Pseudokirchneriella subcapitata (green algae) -

9.170 mg/l - 48 h Remarks: (ECHA)

Toxicity to bacteria

static test IC50 - activated sludge - > 1.000 mg/l - 3 h (OECD Test Guideline 209)

Persistence and degradability

Biodegradability aerobic - Exposure time 20 d

Result: 75 % - Readily biodegradable. Remarks: (ECHA)

Chemical Oxygen Demand (COD)

Theoretical oxygen demand

2.230 mg/g Remarks: (IUCLID)

2.400 mg/g Remarks: (Lit.)

Ratio BOD/ThBOD < 2 %

Bioaccumulative potential

The product is miscible in water and readily biodegradable in both water and soil. Accumulation is not expected.

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

SECTION 13: Disposal considerations

Waste treatment methods

Incompatibilities

Vapors may form explosive mixture with air. Incompatible with oxidizers; contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. n-Propanol reacts with alkali metal, nitrides and strong reducing agents to give flammable and/or toxic gases. Reacts with oxoacids and carboxylic acids to form esters plus water.

Product

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinera- tor equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

SECTION 14: Transport information

UN number

ADR/RID: 1274 IMDG: 1274

UN proper shipping name

ADR/RID: n-PROPANOL IMDG: n-PROPANOL IATA: n-Propanol

Transport hazard class(es)

ADR/RID: 3 IMDG: 3 IATA: 3

Packaging group

ADR/RID: II IMDG: II IATA: II

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no

Special precautions for user

No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/

Measures for Environmental Management of New Chemical Substances

Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/

New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/

EC Inventory:Listed.

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

SECTION 16: Other information

Abbreviations and acronyms

ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
CAS: Chemical Abstracts Service
EC50: Effective Concentration 50%
IATA: International Air Transportation Association
IMDG: International Maritime Dangerous Goods
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
STEL: Short term exposure limit
TWA: Time Weighted Average

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

Use of alcoholic beverages enhances the harmful effect.

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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