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The US Food and Drug Administration is seeing a rising number of reports of pets accidentally overdosing on Apoquel Chewable, a flavoured chewable medicine approved only for dogs.
Accidental overdoses have been reported in both dogs and cats, however cats are greater likely to experience serious side impacts. As of April this year, there have been 259 reports of overdose in dogs and 64 in cats since the medication was approved by the FDA in June 2023.
Apoquel Chewable contains the active ingredient oclacitinib and requires a prescription from a veterinarian. It is applied to manage itching in dogs with skin allergies and to treat a chronic skin condition called atopic dermatitis, which is similar to eczema in people. It is safe and efficiently to dogs older than one year, when applied at the recommended dose, however is not approved to cats.
The pork-liver flavouring in Apoquel Chewable is meant to make the medication appetising and easier to deliver to dogs. However, the flavouring also ends up tempting both dogs and cats to overfeed on the tablets, sometimes an entire bottle’s contents. An overdose of Apoquel Chewable can be life-threatening to both dogs and cats, however cats tend to develop greater severe signs.
Signs of overdose in dogs and cats include vomiting and diarrhoea, lethargy (low energy or decreased activity), redness of the eyes and swelling around the eyes, and impacts on the heart, brain, kidneys, and liver. These signs usually appear within 24 hours after an overdose. The FDA encourages consumers to report untoward incidents to Zoetis, the manufacturer of Apoquel Chewable.
(Source: USFDA)
Published on August 10, 2026
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