The difference between racemization and meso-racemization

In modern chemical production, Solvation technology is a very important process step. Spinning technology mainly refers to the dissolution of solid raw materials into liquid media to improve the activity and efficiency of the reaction. In the process of rotation, racemization (External Dissolution) and meso (Internal Dissolution) are two common ways of rotation, and there are significant differences in principle, equipment, application and advantages and disadvantages. This paper will analyze the core difference between racemization and meso in detail, and discuss their application in chemical production.

1. Spin technology definition and background

The core purpose of the spin technology is to fully dissolve the solid raw material through the liquid medium to improve the efficiency and activity of the subsequent reaction. Spinning technology is widely used in pharmaceutical, fine chemicals production, chemical synthesis and other fields. Due to the high requirements for equipment and process in the spinning process, the selection of the appropriate spinning method is a key factor to be considered in chemical production.

2. The difference between racemization and meso

Racemization and racemization are two common ways of rotation, the difference is mainly reflected in the following aspects:

(1) Equipment structure and operation mode

The racemization usually uses fixed bed or rotary spin tower and other fixed equipment. The spinning medium (such as water, ethanol, etc.) enters the spinning equipment through the feed port, contacts with the solid raw materials, and is fully dissolved. The racemization equipment requires an additional spinning medium circulation system to ensure the continuity and stability of the spinning process.

The meso-racemization uses the fluid spinning technology, and the spinning equipment usually includes a rotating reactor, a cyclone bed, etc. The key of meso is that the spinning medium forms a stable swirling state inside the equipment, so that the solid raw material and the liquid medium are fully contacted, so as to realize the efficient spinning process. The meso equipment usually adopts a self-sufficient spinning medium supply system, without additional recycling equipment, saving equipment investment and energy consumption.

(2) Spinning efficiency and energy consumption

Racemization requires the use of an external spinning medium (such as water, ethanol, etc.) for spinning, and the spinning medium needs to be processed by processes such as preheating and cooling, which increases the complexity and energy consumption of the equipment. The main disadvantage of racemization is the large size of the equipment, and the efficiency of the rotation is limited by the choice of medium and the design of the equipment.

The meso-racemization uses the swirling state of the liquid medium itself to spin through the spinning fluidization technology, without the need for an additional spinning medium, with higher spinning efficiency and lower energy consumption. The compactness and high efficiency of the meso equipment make it widely used in modern chemical production.

(3) Application areas and process advantages

Racemization is widely used in the pharmaceutical industry, for example, in the preparation of APIs (aspirin, butyl acetamide, etc.), racemization technology can improve the solubility and reactivity of raw materials. The flexibility of the racemization equipment is high, suitable for small batch, short cycle production process.

In the production of fine chemicals, for example, in the synthesis of API, meso-racemization technology can achieve efficient dissolution and homogeneous characteristics of solid raw materials. The advantages of meso technology are its high efficiency and stability, which can meet the high demand of modern chemical production.

(4) Equipment maintenance and management

The equipment for racemization is more complex, the circulation and control of the spinning medium requires higher technical requirements, and the equipment maintenance and management costs are higher. Racemization equipment is prone to problems such as blockage and leakage, and professional operators are required for daily maintenance and troubleshooting.

The mesoization equipment has compact structure, relatively simple maintenance and management, and low equipment failure rate. The self-sufficient nature of the meso equipment makes it more stable and reliable in actual production.

3. The advantages and disadvantages of racemization and racemization summary

Racemization:

• Advantages: The equipment structure is simple, the rotation efficiency is high, suitable for small batch, short cycle production process.
• Disadvantages: the equipment is larger, the energy consumption is higher; the selectivity of the spinning medium and the equipment maintenance cost is higher.

Meso-racemization:

• Advantages: the equipment is compact and efficient, and the energy consumption is low; the self-sufficient spinning medium supply system, and the maintenance cost is low.
• Disadvantages: the physical properties of the spin medium requirements are higher; in some cases, the spin efficiency is slightly inferior to the racemization.

4. Racemization and mesocization in the actual production of the application case

Racemization technology has been widely used in the pharmaceutical industry, for example, in the preparation of APIs, racemization technology can significantly improve the solubility and reactivity of raw materials. Through the racemization technology, the production process is more stable, the production of intermediate products is reduced, and the purity of the product is improved.

Meso-racemization technology dominates the production of fine chemicals. For example, during the synthesis of API, meso-racemization technology can achieve efficient dissolution and homogeneous characteristics of solid raw materials. Through the mesocization technology, the production efficiency is significantly improved, and the quality stability of the product is further guaranteed.

5. The future development trend

With the development of spin technology, meso technology will continue to occupy a dominant position in chemical production. In the future, the meso technology will pay more attention to the automation and intelligence of the equipment, such as the introduction of robot spinner and microfluidic technology to further improve the efficiency of spinning and production efficiency. Racemization technology is also being optimized, for example, by improving the choice of spinning media and equipment design to achieve a more efficient and economical spinning process.

Summary

Racemization and meso-racemization are two different spin technologies, and there are significant differences between them in terms of equipment structure, spin efficiency, energy consumption, and application fields. Racemization technology equipment is simple, widely used, but high energy consumption. When choosing a spinning technology, it is necessary to consider the specific production needs, equipment investment and process requirements. With the development of technology, mesocization technology will continue to play an important role in chemical production, promoting the technological progress and efficiency improvement of the whole industry.