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diethyl malonate

CAS

Purity

CHARACTER

diethyl malonate, chemical formula is C7H12O4, is a colorless transparent liquid, with ester-specific fragrance, slightly soluble in water, soluble in ethanol, ether and other organic solvents. Diethyl malonate is an important raw material and solvent for organic synthesis, which is widely used in medicine, pesticide, dye and fragrance industries. In pharmaceutical manufacturing, it is used as a key intermediate for the synthesis of a variety of drugs; in the pesticide industry, diethyl malonate is used to synthesize pesticides and herbicides; in addition, it is also used to synthesize dyes and spices to improve the color and aroma of products; In organic synthesis, diethyl malonate, as an ester compound, participates in a variety of chemical reactions, such as transesterification, acylation, etc. As a multifunctional organic compound, diethyl malonate is widely used in many industrial fields.

APPLICATIONS

(1) As an important intermediate in the field of medicine, diethyl malonate can be used to synthesize a variety of drugs, such as norfloxacin, romefloxacin, chloroquine, phenylbutazone, barbital and sulfanilamide, etc. These drugs have a wide range of applications in the medical industry.

(2) In the food industry, diethyl malonate is used as a flavoring, mainly used to prepare fruit flavors such as pears, apples, grapes, cherries, etc., to add flavor to food and meet the diverse needs of consumers for food taste.

(3) diethyl malonate is also an important raw material in the production of dyes and pigments, and can be used to synthesize benzimidazole ketone organic pigments, etc. These pigments have bright color and good stability, and are widely used in textile, leather, paper and other industries.

(4) In addition, diethyl malonate is also used in the field of pesticides. It is an important intermediate for the preparation of sulfonylurea herbicides such as bensulfuron methyl, prazosulfuron methyl, nicosulfuron methyl, etc. These herbicides are used in agricultural production to control weeds and improve the yield and quality of crops.

INDICATORS

ABILITIES

1. Packing: barreled, scattered water
2. Logistics: car transportation, shipping
3. Payment request: EXW/FOB/FCA/CFR only accepted

HONORARY

Chinese name	diethyl malonate
English Name	Ethyl malonate
Alias	Ethyl malonate propylene glycol diethyl ester carrot acid ethyl ester malonate diethyl ester malonate diethyl ester diethylmalonate carrot acid diethyl ester sodium valproate impurity 22
English alias	NSC 8864 AI3-00656 Malonic ester MALONIC ESTER FEMA No. 2375 Ethyl malonate ETHYL MALONATE UNII-53A58PA183 Diethyl malonate Diethyi malonate Dicarbethoxymethane Ethyl propanedioate Ethyl malonate (VAN) Diethyl propanedioate Carbethoxyacetic ester MALONIC ACID DIETHYL ESTER Ethyl methanedicarboxylate Malonic acid, diethyl ester Propanedioic acid, diethyl ester Propanedioic acid, 1,3-diethyl ester Methanedicarboxylic acid, diethyl ester Malonic Acid Diethyl EsterEthyl Malonate Diethyl malonate,Malonic acid diethyl ester
CAS	105-53-3 145601-68-9
EINECS	203-305-9
Chemical formula	C7H12O4
molecular weight	160.17
InChI	InChI:1S/C7H12O4/c1-3-10-6(8)5-7(9)11-4-2/h3-5H2,1-2H3
InChIKey	IYXGSMUGOJNHAZ-UHFFFAOYSA-N
Density	1.055 g/mL at 25°C (lit.)
Melting Point	-51--50°C (lit.)
Boiling Point	199°C (lit.)
Flash Point	212 °F
water soluble	Miscible with ethyl alcohol, ether, chloroform and benzene. Slightly miscible with water.
Vapor pressure	1mm Hg ( 40 °C)
steam density	5.52 (vs air)
JECFA Number	614
Solubility	20.8g/l (external MSDS)
refractive index	n20/D 1.413(lit.)
acidity coefficient	13.5(at 25℃)
Storage conditions	Store below +30°C.
Stability	Stable. Combustible. Incompatible with strong oxidants,
Sensitivity	Sensitive to humidity
Appearance	Solid
Color	colourless liquid
Smell	Sweet ester odor
Merck	14,3823
BRN	774687
Explosion limit value	0.8-12.8%(V)
physicochemical properties	Colorless liquid with a sweet ether odor. With alcohol, ether miscible, soluble in chloroform, benzene and other organic solvents. Slightly soluble in water. The solubility in water is 2.08g/100ml at 20 ℃.
MDL No.	MFCD00009195
Dangerous Goods Signs	Xi-Irritant Items
Risk Terms	R36/37/38-Irritating to eyes, respiratory system and skin. R36-Irritating to eyes.
Safety terminology	S24/25-Avoid contact with skin and eyes. S26-After contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	1
RTECS	OO0700000
TSCA	Yes
Customs Number	29171910
Hazard Note	Irritant
Upstream raw materials	sulfuric acid monochloroacetic acid hydrochloric acid monochloroacetic acid ethanol
Downstream Products	diethyl n-butylmalonate malonate diethyl ethoxymethylimalonate enoxacin chloroquine phosphate

Nature

Colorless liquid with a sweet ether odor. Relative density of 1. 0551. Melting point -50 ℃. Boiling point 199.3 ℃. Refractive index 1. 4135. Flash point of 100 ℃ with alcohol, ether miscible, soluble in chloroform, benzene and other organic solvents. Slightly soluble in water, the solubility in water at 20°C is 2.08g/lOOmL.

preparation method

Sodium chloroacetate method Chloroacetic acid is neutralized with sodium carbonate at 30°C to form sodium chloroacetate, cyanated with sodium cyanide at 92-95°C, and then hydrolyzed with alkali to form sodium malonate. Sodium malonate is dried and then esterified with ethanol in the presence of sulfuric acid at 70-72°C. The esterification product was washed and distilled to obtain the final product diethyl malonate.
The sodium cyanoacetate method is obtained by direct esterification of cyanoacetic acid with ethanol.

Use

Mainly used in organic synthesis, dyes, spices intermediates, but also the synthesis of chloroquine, Baotai pine, barbital and other pharmaceutical raw materials.

Security

This product is low toxicity, rats oral LD50 >1600 mg/kg, but in the body will be hydrolyzed into acid, to avoid contact. Wash after contact. Operators should wear rubber gloves.
This product is packed in iron drums or galvanized iron drums with a specification of 200kg. Storage and transportation shall be in accordance with the provisions of combustible chemicals.

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