diethyl malonate CAS 105-53-3 manufacturer China product image

diethyl malonate

diethyl malonate (CAS 105-53-3) is an industrial chemical supplied by SKYSEVEN Chemical for global B2B buyers, molecular formula C7H12O4. Request a quote with purity, packing and destination port.

diethyl malonate (CAS 105-53-3) — industrial supply from SKYSEVEN Chemical (Shanghai). On your RFQ include CAS, assay/water limits, packing, quantity and Incoterm. COA and SDS are available on request; commercial reply target ≤24 hours CST.

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CAS

Purity

Category

Nickname

: 105-53-3

:

: Intermediate 

:diethyl propanedioate; Propanedioic acid, diethyl ester; Diethyl Malonate; Ethyl Malonate; Malonic acid diethyl ester;
:diethyl propanedioate; Propanedioic acid, diethyl ester; Diethyl Malonate; Ethyl Malonate; Malonic acid diethyl ester;
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size/weight : Bulk drum IOS Tank

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Product Description

CHARACTER

diethyl malonate, chemical formula is C7H12O4, is a colorless transparent liquid, with ester-specific fragrance, slightly soluble in water, soluble in ethanol, ether and other organic solvents. Diethyl malonate is an important raw material and solvent for organic synthesis, which is widely used in medicine, pesticide, dye and fragrance industries. In pharmaceutical manufacturing, it is used as a key intermediate for the synthesis of a variety of drugs; in the pesticide industry, diethyl malonate is used to synthesize pesticides and herbicides; in addition, it is also used to synthesize dyes and spices to improve the color and aroma of products; In organic synthesis, diethyl malonate, as an ester compound, participates in a variety of chemical reactions, such as transesterification, acylation, etc. As a multifunctional organic compound, diethyl malonate is widely used in many industrial fields.

APPLICATIONS

(1) As an important intermediate in the field of medicine, diethyl malonate can be used to synthesize a variety of drugs, such as norfloxacin, romefloxacin, chloroquine, phenylbutazone, barbital and sulfanilamide, etc. These drugs have a wide range of applications in the medical industry.

(2) In the food industry, diethyl malonate is used as a flavoring, mainly used to prepare fruit flavors such as pears, apples, grapes, cherries, etc., to add flavor to food and meet the diverse needs of consumers for food taste.

(3) diethyl malonate is also an important raw material in the production of dyes and pigments, and can be used to synthesize benzimidazole ketone organic pigments, etc. These pigments have bright color and good stability, and are widely used in textile, leather, paper and other industries.

(4) In addition, diethyl malonate is also used in the field of pesticides. It is an important intermediate for the preparation of sulfonylurea herbicides such as bensulfuron methyl, prazosulfuron methyl, nicosulfuron methyl, etc. These herbicides are used in agricultural production to control weeds and improve the yield and quality of crops.


INDICATORS

ABILITIES

1. Packing: barreled, scattered water
2. Logistics: car transportation, shipping
3. Payment request: EXW/FOB/FCA/CFR only accepted

HONORARY

CAS Number105-53-3
Molecular FormulaC7H12O4
Molecular Weight160.168
Melting Point -50°C
Boiling Point 199?°C(lit.)
Density 5.52(vsair)
Flash Point 212?°F
Refractive Index n20/D1.413(lit.)
Vapor Pressure 0.344mmHgat25°C
Catalog packing0 / 78 / 79 / 81

Key facts for buyers (2026-07)

diethyl malonate (CAS 105-53-3, formula C7H12O4) is traded as an industrial chemical feedstock/solvent. B2B buyers in 2026 typically lock identity by CAS, request lot COA + SDS before PO, and specify packing (drum/IBC/ISO tank) plus Incoterm on the RFQ. SKYSEVEN Chemical (Shanghai) targets commercial replies within 24 hours (CST, UTC+8). Cross-check identity data in PubChem / NIST / CAS Common Chemistry before first import.

Sources & references:

Buyer checklist

  • Write full chemical name + CAS 105-53-3 on every RFQ and PO.
  • State purity/assay, critical impurities, packing and monthly quantity.
  • Choose Incoterm (EXW/FOB/CIF) with your freight forwarder before comparing quotes.
  • Request COA + SDS (language) before first shipment; archive with the PO.
  • Confirm lead time in writing; SKYSEVEN Chemical works on Shanghai time (CST).
  • Common packing options on catalog: 0,78,79,81. Confirm available packing and MOQ on the RFQ.

Next step: Request a quote for CAS 105-53-3 · RFQ template · WhatsApp +86-191-1728-8062

Sourcing pattern (example)

Example sourcing pattern: a coatings or intermediate manufacturer confirms diethyl malonate by CAS 105-53-3, requests assay/water limits on RFQ, compares FOB vs CIF landed cost, and releases payment only after draft COA/SDS review. Replace this pattern with a customer-approved case study when available.

Trust & fulfilment

  • diethyl malonate inquiries should include CAS identity for document alignment.
  • Industrial grades are standard; tighter specs require written limits on the RFQ.
  • Export documents (COA/SDS) available on request for orders.
  • Packing and Incoterms confirmed before order finalization.
  • Technical questions handled by SKYSEVEN Chemical specialist roles (see Authors).

Last reviewed: 2024-12-03 · By SKYSEVEN Chemical Technical Team · Authors · Trust center · Research · Compliance

Applications of diethyl malonate

  • Fine chemical and pharmaceutical intermediate synthesis
  • Agrochemical active ingredient routes
  • Specialty chemical and dye intermediate production

How to buy diethyl malonate from SKYSEVEN Chemical

  1. Confirm product identity: chemical name, CAS number, purity and required packing.
  2. Submit an inquiry on cnchemshop.com with destination country, quantity and Incoterm preference.
  3. Review quotation, lead time, and document list (COA, SDS, origin certificate if needed).
  4. Confirm order terms (T/T or L/C), packing and shipping mode (sea/air as applicable).
  5. Receive shipment documents and track delivery to your port or warehouse.

Reference data sources

FAQ — diethyl malonate

What is diethyl malonate?

diethyl malonate (CAS 105-53-3) has molecular formula C7H12O4. SKYSEVEN Chemical supplies industrial grades for B2B export; specifications are confirmed on COA.

What is the CAS number of diethyl malonate?

The CAS Registry Number of diethyl malonate is 105-53-3. Verify with free CAS lookup: cnchemshop.com/tools/cas-lookup.html or /cas/105-53-3.html.

How to buy diethyl malonate from China?

Request a quote on cnchemshop.com for diethyl malonate (CAS 105-53-3). State purity, packing, quantity and destination port. SKYSEVEN Chemical provides COA/SDS and aims to reply within 24 hours (CST, UTC+8).

What are the key physical properties of diethyl malonate?

Key properties of diethyl malonate include melting point -50°C, boiling point 199?°C(lit.), density 5.52(vsair). Always verify against the latest COA and SDS for your lot.

Chinese name diethyl malonate
English Name Ethyl malonate
Alias Ethyl malonate
propylene glycol diethyl ester
carrot acid ethyl ester
malonate diethyl ester
malonate diethyl ester
diethylmalonate
carrot acid diethyl ester
sodium valproate impurity 22
English alias NSC 8864
AI3-00656
Malonic ester
MALONIC ESTER
FEMA No. 2375
Ethyl malonate
ETHYL MALONATE
UNII-53A58PA183
Diethyl malonate
Diethyi malonate
Dicarbethoxymethane
Ethyl propanedioate
Ethyl malonate (VAN)
Diethyl propanedioate
Carbethoxyacetic ester
MALONIC ACID DIETHYL ESTER
Ethyl methanedicarboxylate
Malonic acid, diethyl ester
Propanedioic acid, diethyl ester
Propanedioic acid, 1,3-diethyl ester
Methanedicarboxylic acid, diethyl ester
Malonic Acid Diethyl EsterEthyl Malonate
Diethyl malonate,Malonic acid diethyl ester
CAS 105-53-3
145601-68-9
EINECS 203-305-9
Chemical formula C7H12O4
molecular weight 160.17
InChI InChI:1S/C7H12O4/c1-3-10-6(8)5-7(9)11-4-2/h3-5H2,1-2H3
InChIKey IYXGSMUGOJNHAZ-UHFFFAOYSA-N
Density 1.055 g/mL at 25°C (lit.)
Melting Point -51--50°C (lit.)
Boiling Point 199°C (lit.)
Flash Point 212 °F
water soluble Miscible with ethyl alcohol, ether, chloroform and benzene. Slightly miscible with water.
Vapor pressure 1mm Hg ( 40 °C)
steam density 5.52 (vs air)
JECFA Number 614
Solubility 20.8g/l (external MSDS)
refractive index n20/D 1.413(lit.)
acidity coefficient 13.5(at 25℃)
Storage conditions Store below +30°C.
Stability Stable. Combustible. Incompatible with strong oxidants,
Sensitivity Sensitive to humidity
Appearance Solid
Color colourless liquid
Smell Sweet ester odor
Merck 14,3823
BRN 774687
Explosion limit value 0.8-12.8%(V)
physicochemical properties Colorless liquid with a sweet ether odor. With alcohol, ether miscible, soluble in chloroform, benzene and other organic solvents. Slightly soluble in water. The solubility in water is 2.08g/100ml at 20 ℃.
MDL No. MFCD00009195
Dangerous Goods Signs Xi-Irritant Items
Risk Terms R36/37/38-Irritating to eyes, respiratory system and skin.
R36-Irritating to eyes.
Safety terminology S24/25-Avoid contact with skin and eyes.
S26-After contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany 1
RTECS OO0700000
TSCA Yes
Customs Number 29171910
Hazard Note Irritant
Upstream raw materials sulfuric acid monochloroacetic acid hydrochloric acid monochloroacetic acid ethanol
Downstream Products diethyl n-butylmalonate malonate diethyl ethoxymethylimalonate enoxacin chloroquine phosphate

 

Nature

Colorless liquid with a sweet ether odor. Relative density of 1. 0551. Melting point -50 ℃. Boiling point 199.3 ℃. Refractive index 1. 4135. Flash point of 100 ℃ with alcohol, ether miscible, soluble in chloroform, benzene and other organic solvents. Slightly soluble in water, the solubility in water at 20°C is 2.08g/lOOmL.

preparation method

  1. Sodium chloroacetate method Chloroacetic acid is neutralized with sodium carbonate at 30°C to form sodium chloroacetate, cyanated with sodium cyanide at 92-95°C, and then hydrolyzed with alkali to form sodium malonate. Sodium malonate is dried and then esterified with ethanol in the presence of sulfuric acid at 70-72°C. The esterification product was washed and distilled to obtain the final product diethyl malonate.
  2. The sodium cyanoacetate method is obtained by direct esterification of cyanoacetic acid with ethanol.

Use

Mainly used in organic synthesis, dyes, spices intermediates, but also the synthesis of chloroquine, Baotai pine, barbital and other pharmaceutical raw materials.

Security

  • This product is low toxicity, rats oral LD50 >1600 mg/kg, but in the body will be hydrolyzed into acid, to avoid contact. Wash after contact. Operators should wear rubber gloves.
  • This product is packed in iron drums or galvanized iron drums with a specification of 200kg. Storage and transportation shall be in accordance with the provisions of combustible chemicals.

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