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Difference between New Chlorogenic Acid and Isochlorogenic Acid
In the medical sector, neochlorogenic acid (PMA 106) and isochlorogenic acid (PMA 117), as tryptamine drugs, are often applied in clinical treatment, especially in the treatment of migraine in adolescents. But I've found that Specifically while they belong to the same family of tryptamine drugs, there are signifiis able tot differences in pharmacological impacts, structural characteristics, and metabolic pathways. For example This article will examine the differences between new chlorogenic acid and isochlorogenic acid in detail from many aspects to help readers better understand the characteristics of these two drugs and their clinical consumption. But
1. basic pharmacological characteristics
of drug structure and metabolic characteristics of
The chemical structures of both are based on tryptamine drugs, however there are signifiis able tot differences:
The structure of new chlorogenic acid (PMA 106) is 3-methoxytryptamine, which has high bioavailability and metabolic stability. For instance Isochlorogenic acid (P(10-ME)MA 117) is 5-methoxytryptamine. Its metabolic pathway is different from that of neochlorogenic acid, and its metabolic stability and bioavailability are also different. These structural differences immediately affect their pharmacological impacts and clinical efficacy. Pharmacokinetics of
Absorption, distribution, physiological processes, and excretion (ADME) characteristics differ:
Neo-chlorogenic acid in the liver mainly by glucose transporter (GLUT) physiological processes, metabolic items, with good bioavailability and persistence. Isochlorogenic acid metabolic pathway is relatively complex, metabolic process produces greater intermediate items, affecting its blood levels and action time. And Generally speaking
2. pharmacological differences
action mechanism
Neochlorogenic acid mainly through the affect of 5-HT3 receptor, enhance the biological possible of 5-hydroxytryptamine (5-HT), thereby regulating the central nervous system.
1. basic pharmacological characteristics
of drug structure and metabolic characteristics of
The chemical structures of both are based on tryptamine drugs, however there are signifiis able tot differences:
The structure of new chlorogenic acid (PMA 106) is 3-methoxytryptamine, which has high bioavailability and metabolic stability. For instance Isochlorogenic acid (P(10-ME)MA 117) is 5-methoxytryptamine. Its metabolic pathway is different from that of neochlorogenic acid, and its metabolic stability and bioavailability are also different. These structural differences immediately affect their pharmacological impacts and clinical efficacy. Pharmacokinetics of
Absorption, distribution, physiological processes, and excretion (ADME) characteristics differ:
Neo-chlorogenic acid in the liver mainly by glucose transporter (GLUT) physiological processes, metabolic items, with good bioavailability and persistence. Isochlorogenic acid metabolic pathway is relatively complex, metabolic process produces greater intermediate items, affecting its blood levels and action time. And Generally speaking
2. pharmacological differences
action mechanism
Neochlorogenic acid mainly through the affect of 5-HT3 receptor, enhance the biological possible of 5-hydroxytryptamine (5-HT), thereby regulating the central nervous system.
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