888CHEM
Difference between New Chlorogenic Acid and Isochlorogenic Acid
In the medical industry, neochlorogenic acid (PMA 106) and isochlorogenic acid (PMA 117), as tryptamine drugs, are often used in clinical treatment, especially in the treatment of migraine in adolescents. Although they belong to the same family of tryptamine drugs, there are significant differences in pharmacological effects, structural characteristics, and metabolic pathways. This article will analyze the differences between new chlorogenic acid and isochlorogenic acid in detail from many aspects to help readers better understand the characteristics of these two drugs and their clinical application.
1. basic pharmacological properties
- The chemical structures of both are based on tryptamine drugs, but there are significant differences:
of drug structure and metabolic characteristics of
-
The structure of
- new chlorogenic acid (PMA 106) is 3-methoxytryptamine, which has high bioavailability and metabolic stability. Isochlorogenic acid
- (P(10-ME)MA 117) is 5-methoxytryptamine. Its metabolic pathway is different from that of neochlorogenic acid, and its metabolic stability and bioavailability are also different.
These structural differences directly affect their pharmacological effects and clinical efficacy.
- Absorption, distribution, metabolism, and excretion (ADME) characteristics differ:
Pharmacokinetics of
- Neo-chlorogenic acid in the liver mainly by glucose transporter (GLUT) metabolism, metabolic products, with good bioavailability and persistence.
- Isochlorogenic acid metabolic pathway is relatively complex, metabolic process produces more intermediate products, affecting its blood concentration and action time.
2. pharmacological differences
- action mechanism
- Neochlorogenic acid mainly through the influence of 5-HT3 receptor, enhance the biological potential of 5-hydroxytryptamine (5-HT), thereby regulating the central nervous system
Get a Free Quote
